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KE0073

Biochemistry, continuation

The course is aimed at those who wish to learn more about molecular regulation of biological processes during normal development and disease. The lectures are interspersed with practical exercises and brainstorming seminars so that you will have the best possible conditions to grasp biochemical principles through discussing and reflecting on their relevance to everyday life. The previous knowledge in the basics of chemistry is required.

Remarkable precision, perfection and logic of biomolecules and biochemical pathways achieved during evolution underlie all aspects of surrounding life and human activities. Likewise, scientific progress in biochemistry is immense and is a driving force of medicine, biotechnology, agriculture, and food industry among other areas. Irrespective of what path of career you will chose in future, biochemical knowledge will always help and sometimes will be even critically necessary in problem-solving.

Instead of providing you with all-embracing theoretical knowledge of biochemistry, which would take many years of studies, the course shall rather make you interested in the subject
and help navigate you in finding explanations for various biological phenomena. Furthermore, the course will facilitate your better understanding of cell biology, immunology and genetics, i.e. other subjects closely related to biochemistry.

Dear Students of the KE0073 course,

I have uploaded preliminary schedule of the course.

It is preliminary because we do not know at the moment whether and how much we will be allowed to teach on campus when course starts at the end of February. Let's hope the virus will fall back and we meet more in a real class room!

I will upload finalized schedule one-two weeks before the course starts.

In the meantime, do not hesitate to contact us, teachers, if you have any questions.

All the best,

On behalf of the teachers' team,

Peter

(prof Peter Bozhkov)

The course evaluation is not yet activated

The course evaluation is open between 2022-03-16 and 2022-04-06

KE0073 Biochemistry, continuation, 7.5 Credits

Biokemi, fortsättningskurs

Syllabus approved

2020-12-10

Subjects

Biology Chemistry

Education cycle

Bachelor’s level

Advanced study in the main field

First cycle, less than 60 credits from first-cycle courses as entry requirements(G1F)

Grading scale

5:Pass with Distinction, 4:Pass with Credit, 3:Pass, U:Fail The requirements for attaining different grades are described in the course assessment criteria which are contained in a supplement to the course syllabus. Current information on assessment criteria shall be made available at the start of the course.

Language

Swedish

Prior knowledge

Knowledge and skills in fundamentals of chemistry corresponding to 15 hp

Objectives

The aim of the course is to give advanced knowledge and skills within biochemistry.

On completion of the course, the student should be able to:
1. account at a general level for different technologies for analysis and structural studies of proteins
2. describe and illustrate principles of enzyme catalysis, kinetics and regulation
3. identify structural and functional parts in protein molecules and relate them to the biological function of the protein (e g catalytic mechanism at enzymes, receptor mechanism)
4. account at a general level for methods to generate and use biological information (gene technology and bioinformatics)
5. describe how lipids carbohydrates and proteins are metabolized and synthesised
6. present and discuss metabolism in connection with overweight nutritional intake, training, starvation, diabetes and cancer
7. relate symptoms on deficit/surplus/genetic defects to metabolic disturbances at a biochemical level
8. present biochemical problem-solving in the form of seminars
9. carry out processing and analysis of data from biochemical experiments and to present these in writing

Content

Lectures, teaching sessions, computer practicals, seminars and exercises are used in the course. Some activities are conducted in small groups, while others are not.
Roll call and course introduction, seminars, computer practicals, and group exercises are compulsory components.
Written and oral presentations are carried out through presenting results from computer practicals , seminars and group exercises. The course consists of both biochemical theory and of solving biochemical problem.
The following items are treated in lectures, teaching sessions, seminars and laboratory sessions:
- technologies for purification, analysis and structural studies of proteins
- gene technology, bioinformatics, "omics" (genomics, transcriptomics, proteomics, metabolomics), recombinant gene expression
- enzymes: catalytic mechanisms, regulation of activity, allostery, efficiency, specificity, enzyme-assays
- carbohydrate metabolism: the pentose phosphate pathway, gluconeogenesis, the glycogen, reciprocal regulation
- metabolism of fats, lipids, amino acids, proteins, nucleotides, nitrogen metabolism
- integration of metabolism: nutritional intake, homeostasis, hormonal control, body weight, BMI, overweight, training, starvation, alcohol
-membrane channels, pumps, signal transduction, sensory systems, receptors

Formats and requirements for examination

Examination formats: Written examination and approved compulsory activities .
Passing the course requires: Approved examination, approved participation in compulsory activities.
  • If the student fails a test, the examiner may give the student a supplementary assignment, provided this is possible and there is reason to do so.
  • If the student has been granted special educational support because of a disability, the examiner has the right to offer the student an adapted test, or provide an alternative assessment.
  • If changes are made to this course syllabus, or if the course is closed, SLU shall decide on transitional rules for examination of students admitted under this syllabus but who have not yet passed the course.
  • For the examination of a degree project (independent project), the examiner may also allow the student to add supplemental information after the deadline. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Other information

  • The right to take part in teaching and/or supervision only applies to the course date to which the student has been admitted and registered on.
  • If there are special reasons, the student may take part in course components that require compulsory attendance at a later date. For more information on this, please refer to the regulations for education at Bachelor's and Master's level.

Additional information

The entry requirements can be achieved e g by having followed the courses in basic chemistry I and II comprising in total 22.5 credits with at least 15 credits passed results.
Some learning activities may be conducted in English.

Responsible department

Department of Molecular Sciences

Further information

Determined by: Programnämnden för utbildning inom naturresurser och jordbruk (PN - NJ)
Biology field: Molekylärbiologi
Replaces: KE0064

After completion of the course students should be able to:

  1. Examine and explain the relationships between structure of a macromolecule, especially of a protein, its biochemical activity and its functional role in a particular biochemical pathway.
  2. Examine and explain the role of a particular biochemical pathway in normal development and disease, at the cellular and organismal levels.
  3. Discuss basic metabolism and integrate major metabolic processes into health and disease states.

Learning goal

Grading criteria

3 (G)

4 (VG)

5 (MVG)

1

Describe how protein activity can be regulated by altering its structure.

Describe and illustrate how protein activity and the whole biochemical pathway can be regulated by altering protein structure.

Correlate protein structure, protein activity and biochemical pathway in the context of normal development and disease, at the cellular and organismal levels.

2

Describe the role of basic biochemical pathways in normal development and disease.

Connect cellular and organismal roles of biochemical pathways in the context of normal development and disease.

3

Describe major metabolic processes and how they are regulated.

Compare major metabolic processes in health versusdisease.

Reflect on health and disease states from metabolome viewpoint.

NB! All compulsory parts of the course should be fulfilled for all grades; i.e. participation in all computer practicals, group exercises, invited seminars and student seminar presentations.

1) Biochemistry
Author: J.M. Berg, J.L. Tymoczko, G.J. Gatto, Jr., L. Stryer
ISBN: 978-1-319-11467-1
Comments: Sidhänvisningar ges till senaste upplagan 9th edition. Tidigare upplagor 8th och 7th ed fungerar också.

Course facts

The course is offered as an independent course: Yes The course is offered as a programme course: Food Science (BSc) Tuition fee: Tuition fee only for non-EU/EEA/Switzerland citizens: 19027 SEK Cycle: Bachelor’s level
Subject: Biology Chemistry
Course code: KE0073 Application code: SLU-30177 Location: Uppsala Distance course: No Language: Swedish Responsible department: Department of Molecular Sciences Pace: 100%